Search results for "Bullous pemphigoid"

showing 4 items of 4 documents

Retrospective Analysis of Checkpoint Inhibitor Therapy-Associated Cases of Bullous Pemphigoid From Six German Dermatology Centers

2021

Immune-related adverse events (irAEs) are a class-effect of checkpoint inhibitors (CIs). The development of a Bullous pemphigoid (BP)-like blistering disease, driven by autoantibodies against the hemidesmosomal protein BP180, is a potentially serious irAE whose incidence seems to be increasing. We therefore set out to characterize the clinical and (immuno)histopathological features and treatment responses of cases of BP which developed during or after CI therapy collated in six German tertiary referral centers between 2014 and 2018. We identified twelve cases of BP which emerged during and/or after CI therapy. The time interval between the initiation of CI therapy and the diagnosis of BP wa…

0301 basic medicineMalelcsh:Immunologic diseases. Allergymedicine.medical_specialtyPD-1 - PD-L1 axisautoantibodiesImmune checkpoint inhibitorsImmunologypemphigoid diseaseIpilimumabPembrolizumabDermatology030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineAntineoplastic Agents ImmunologicalAdrenal Cortex HormonesInternal medicineGermanyNeoplasmsPemphigoid BullousmedicineHumansImmunology and AllergyipilimumabAdverse effectImmune Checkpoint InhibitorsAgedRetrospective StudiesOriginal ResearchAged 80 and overnivolumabbusiness.industryIncidence (epidemiology)autoimmunityAutoantibodyMiddle Agedmedicine.disease030104 developmental biologyFemaleBullous pemphigoidpembrolizumabNivolumabbusinesslcsh:RC581-607checkpoint inhibitorsmedicine.drugFrontiers in Immunology
researchProduct

Number 1Epithelial biology

2005

The oral mucous membrane has features similar to skin but also differs in several ways. This paper reviews the aspects of epithelial biology necessary for an understanding of the vesiculoerosive disorders.

Pathologymedicine.medical_specialtybiologyAdenomatous polyposis coliOral mucous membranemacromolecular substancesEpitheliummedicine.anatomical_structureOtorhinolaryngologyGSK-3Bullous Pemphigoid Antigenmedicinebiology.proteinCancer researchGeneral DentistryOral Diseases
researchProduct

Systemic lupus erythematosus and bullous pemphigoid with dramatic response to dapsone

2017

Patient: Female, 11 Final Diagnosis: Bullous pemphigoid in systemic lupus erythematosus Symptoms: Bullous lupus • photosensitive rash • synovitis Medication:— Clinical Procedure: Pharmacological treatment Specialty: Rheumatology Objective: Unusual clinical course Background: Bullous pemphigoid is an autoimmune blistering disease, with relapses, isolated or associated with other autoimmune diseases such as systemic lupus erythematosus (SLE). Joint manifestations rapidly respond to small or moderate doses of corticosteroids, whereas skin manifestations usually respond to antimalarial drugs. Case Report: We describe the clinical case of an 11-year-old girl with SLE. She showed bullous skin les…

Pemphigoidmedicine.medical_specialtyAntimalarials; Child; Dapsone; Female; Humans; Lupus Erythematosus Systemic; Pemphigoid BullousMild proteinuriaArthritisDapsoneAntimalarials030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineSettore MED/38 - Pediatria Generale E SpecialisticaPrednisoneimmune system diseasesPemphigoid BullousmedicineHumansChildskin and connective tissue diseases030203 arthritis & rheumatologyLupus erythematosusintegumentary systembusiness.industryMedicine (all)Dapsone; Lupus erythematosus systemic; Pemphigoid bullous; Medicine (all)ArticlesGeneral Medicinemedicine.diseasePemphigoid bullouDermatologyeye diseasesLupus erythematosus systemicFemaleBullous pemphigoidsense organsbusinessDapsonemedicine.drugPediatric population
researchProduct

Diagnostics of autoimmune bullous diseases in German dermatology departments

2012

Summary Background: No consistent data are available on the currently employed diagnostic tools for autoimmune bullous diseases in Germany. The aim of this survey was to describe currently performed diagnostic methods for bullous autoimmune diseases in German dermatology departments. Methods: A standardized questionnaire evaluated the available diagnostic methods i. e. direct immunofluorescence microscopy (IFM), indirect IFM, commercial ELISA systems, and non-commercial serological tests as well as the number of samples per year in all 34 university and 39 non-university dermatology departments. Results: The overall return rate was 89 %, 100 % and 79 % for the university and non-university …

Pemphigoidmedicine.medical_specialtyDiagnostic methodsbusiness.industryDiagnostic testDermatologymedicine.diseaseDiagnostic toolsDermatologyhumanities3. Good healthSerology030207 dermatology & venereal diseases03 medical and health sciencesPemphigus0302 clinical medicine030220 oncology & carcinogenesisMedicineBullous pemphigoidbusinessDirect fluorescent antibodyJDDG: Journal der Deutschen Dermatologischen Gesellschaft
researchProduct